2025.12-至今 天津大学，英才教授，博士生导师

2019.09-2025.11 美国威斯康辛大学-麦迪逊分校 药学院  博士后 （合作导师：Li Lingjun教授）

2016.09-2019.06 吉林大学 博士 （导师：陈焕文 教授）

1． 生命多组学质谱分析

2． 分子空间可视化质谱成像研究

围绕化学-医学交叉领域的前沿方向，已取得了一系列创新性成果，开发了超高空间分辨质谱成像新技术及新型原位质谱分析方法，为复杂临床生物样品和单细胞的快速检测、多组学空间可视化研究提供了重要基础。目前已发表研究论文59篇，其中以第一作者或通迅作者身份在Nature Methods，Nature Communications，Chemical Science和Analytical Chemistry等国际著名学术期刊上发表论文23篇。

1. Hua Zhang#, Lang Ding#, Amy Hu, Xudong Shi, Penghsuan Huang, Haiyan Lu, Paul W Tillberg*, Meng C Wang*, Lingjun Li*, TEMI: Tissue Expansion Mass Spectrometry Imaging, Nature Methods, 2025, 22: 1051–1058 https://doi.org/10.1038/s41592-025-02664-9 (#Co-first author, *Corresponding).

2. Hua Zhang, Yuan Liu, Lauren Fields, Xudong Shi, Penghsuan Huang, Haiyan Lu, Andrew J Schneider, Xindi Tang, Luigi Puglielli, Nathan V Welham, Lingjun Li*. Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging, Nature Communications, 2023, 14: 5185.

3. Hua Zhang, Daniel G Delafield, Lingjun Li*. Mass spectrometry imaging: the rise of spatially resolved single-cell omics, Nature Methods, 2023, 20(3): 327-330.

4. Hua Zhang, Meng Xu, Xudong Shi, Yuan Liu, Zihui Li, Justin C Jagodinsky, Min Ma, Nathan V Welham, Zachary S Morris, Lingjun Li*. Quantification and molecular imaging of fatty acid isomers from complex biological samples by mass spectrometry, Chemical Science, 2021, 12(23): 8115-8122.

5. Hua Zhang, Xudong Shi, Haiyan Lu, Lingjun Li*. Delineation of subcellular molecular heterogeneity in single cells via ultralow-flow-rate desorption electrospray ionization mass spectrometry imaging, Analytical Chemistry, 2025, 97, 18, 9985–9991.

6. Hua Zhang, Xudong Shi, Nhu Q Vu, Gongyu Li, Zihui Li, Yatao Shi, Miyang Li, Bin Wang, Nathan V Welham, Manish S Patankar, Paul Weisman, Lingjun Li*. On-tissue derivatization with Girard’s reagent P enhances N-glycan signals for formalin-fixed paraffin-embedded tissue sections in MALDI mass spectrometry imaging, Analytical Chemistry, 2020, 92(19): 13361-13368. Featured as an ACS Editor’s Choice Article.

7. Hua Zhang, Konstantin Chingin, Jiajia Li, Haiyan Lu, Keke Huang*, Huanwen Chen*. Selective Enrichment of Phosphopeptides and Phospholipids from Biological Matrixes on TiO₂ Nanowire Arrays for Direct Molecular Characterization by Internal Extractive Electrospray Ionization Mass Spectrometry, Analytical Chemistry, 2018, 90(20): 12101-12107.

8. Hua Zhang, Haiyan Lu, Konstantin Chingin*, Huanwen Chen*. Stabilization of proteins and noncovalent protein complexes during electrospray ionization by amino acid additives, Analytical Chemistry, 2015, 87(14): 7433-7438.

9. Hua Zhang, Konstantin Chingin, Liang Zhu, Huanwen Chen*, Molecular characterization of ongoing enzymatic reactions in raw garlic cloves using extractive electrospray ionization mass spectrometry, Analytical Chemistry, 2015, 87(5): 2878-2883.

10. Hua Zhang, Malik Ebbini, Thao Duong, Kendra G. Selby, Kelly H. Lu, Emily Hubecky, Haiyan Lu, Lingjun Li*, Single-cell mass spectrometry imaging: emerging advancements and future insights, Analytica Chimica Acta, 2026, 1382, 8, 344825

 完整论文清单见：https://scholar.google.com/citations?user=05nkf8cUZugC&hl=en

国家海外高层次青年人才计划。曾在研究生阶段荣获中国青少年科技创新奖（2016年，国家级），博士后研究期间获美国质谱协会博士后职业发展奖（ASMS Postdoctoral Career Development Award, 2022），被Anal. Bioanal. Chem.期刊评为杰出博士后学者(Excellent Postdoctoral Researcher, 2021)等重要奖项。

本课题组长期招收有分析化学、有机合成、生物、智能制造等相关方向的硕士和博士研究生。另外我们长年诚聘博士后和科研助理，课题组将提供有竞争力的薪酬，表现优秀者将有机会被推荐至国内外一流高校或研究机构深造。有意者请将简历发送至hzhang7@tju.edu.cn

Dr. Hua Zhang is a Professor in the School of Science, Department of Chemistry at Tianjin University, specializing in analytical chemistry. He earned his PhD from Jilin University in 2019 and subsequently completed postdoctoral training at the University of Wisconsin–Madison, School of Pharmacy from 2019 to 2025. His research focuses on mass spectrometry imaging and mass spectrometry–based multi-omics analysis. He has established a suite of highly sensitive, ultrahigh-spatial-resolution mass spectrometry imaging methodologies, together with innovative ambient ionization in situ mass spectrometry analysis approaches, to enable single-cell–level spatial multi-omics investigations of clinical tissues and rapid analysis of complex biospecimens. To date, he has published 59 peer-reviewed articles, including 23 as first or corresponding author in leading journals such as Nature Methods, Nature Communications, Chemical Science, and Analytical Chemistry.