1、承担大学本科生专业必修课《精细有机合成》、《高等有机化学》

2、研究生专业必修课《有机合成化学》、《高等有机合成》及《化学前沿进展》

1、手性化合物不对称合成研究：包括（1）新型手性催化剂设计合成；（2）催化不对称新反应及新合成方法研究；（3）具生物活性的手性化合物设计合成有机氟化学工程化研究

2、有机氟化学工程化研究：包括（1）含氟有机功能化合物的设计、合成及反应研究；（2）18F－PET成像探针及药物设计合成，主要用于肿瘤诊断；（3）天然产物及药物氟工程化修饰及活性筛选，主要用于创制新药物

1、1997年度广东省新产品研发三等奖；

2、1998年度广州市科技进步二等奖；

3、2003年中国化工学会优秀论文奖；

4、2005年度入选教育部新世纪优秀人才；

5、2006年度入选天津市“131”创新型人才培养工程（第一层次）

6、2007年度获得天津市五一劳动奖章

7、2008年度入选国务院政府特贴专家

8、2008年度被评为天津市优秀留学回国人员

9、2010年法国应用科学研究所(INSA)客座教授

10、2012年度国家杰出青年科学基金获得者

11、2012年度教育部宝钢优秀教师奖获得者

12、2013年获得“Thieme Chemistry Journal Award”国际期刊学术奖励

13、2016年获得天津市教育系统优秀共产党员称号

目前成员：

毕业成员：

目前与欧、美、日三个有机化学实验室建立国际合作关系：

（1）法国国家科学研究中心(CNRS)精细化学研究所(IRCOF)及鲁昂大学：

Prf. Dr. Dominique Cahard

UMR 6014 CNRS, laboratoire COBRA de l'IRCOF, Université et INSA de Rouen,

Rue Tesniere, F-76130 Mont Saint Aignan, France

Email: Dominique.Cahard@univ-rouen.fr

(2)日本理化学研究所(RIKEN)

Prof. Dr. Mikiko Sodeoka

Synthetic Organic Chemistry Lab

RIKEN (The Institute of Physical and Chemical Research)

2-1 Hirosawa, Wako, Saitama 351-0198, Japan

E-mail: sodeoka@riken.jp

（3）美国德州大学（圣安东尼奥）

Prof. Dr. John Conggui Zhao

Department of Chemistry,

University of Texas at San Antonio,

Email: cong.zhao@utsa.edu

（4）美国南加州大学

Prof. Dr. Kai Chen

Molecular Imaging Center & Keck School of Medicine,

University of Southern California

Email: chenkai@usc.edu

目前发表学术论文120多篇，论文被他引用次数达三千八百余次。申请专利15项（其中7项已获授权），参编书籍5部，作为项目负责人，先后承担和完成国家、省部级科研目项十多项。参见国际国内学术会议，被邀请做大会及口头报告近三十余次。

近年发表期刊论文

1. Nan Ren, Jing Nie, Jun-An Ma*, Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water, Green Chem. 2016, 18, 6609-6617.

2. Zhen-Yan Yang, Jun-Liang Zeng, Nan Ren, Wei Meng, Jing Nie, and Jun-An Ma*, C2-Symmetric Chiral Bisoxazolines as Hydrogen-Bond-Acceptor Catalysts in Enantioselective Aldol Reaction of β-Carbonyl Acids with Trifluoroacetaldehyde Hemiacetals, Org. Lett. 2016, 18, 6364-6367.

3. Chun-Man Jia, Heng-Xia Zhang, Jing Nie, Jun-An Ma*, Catalytic Asymmetric Decarboxylative Mannich Reaction of Malonic Acid Half Esters with Cyclic Aldimines: Access to Chiral β?Amino Esters and Chroman-4-amines, J. Org. Chem., 2016, 81, 8561?8569.

4. Ran Guo, Yan Zheng, Jun-An Ma*，Electrophilic Reaction of 2,2,2-Trifluoro-diazoethane with the in Situ Generated N?Heterocyclic Carbenes: Access to N-Aminoguanidines, Org. Lett. 2016, 18, 4170-4173.

5. Yi Wei, Ran Guo, Yanfeng Dang, Jing Nie, Jun-An Ma*, Organocatalytic Enantioselective Decarboxylative Michael Addition of β-Ketoacids to Dicyanoolefins and Disulfonyl-olefins, Adv. Synth. Catal. 2016, 358, 2721-2726.

6. Li-Jun Yang, Jun-An Ma*, New Advances on Nucleophilic Phosphine-Triggered Annulation Reactions of Allenoates, Acta Chim. Sinica 2016, 74, 130?148.

7. Chuan-Le Zhu, Jun-An Ma*, Dominique Cahard*, Trifluorodiazoethane (CF3CHN2) in the Uncatalyzed Cyclopropanation of 3-Arylmethylenebenzofuran-2(3H)-ones, Asian J. Org. Chem. 2016, 5, 66–69.

8. Yan Zheng, Hai Ma, Jun-An Ma*, Catalytic Enantioselective 1,2-Addition of Terminal 1,3-Diynes to Trifluoromethyl Ketones, Chin. J. Chem. 2016, 34, 511?518.

9. Bo-Nan Lai, Jian-Feng Qiu, Heng-Xia Zhang, Jing Nie, Jun-An Ma*, Stereoselective Synthesis of Fused Aziridines via One-Pot Sequential Decarboxylative Mannich Reaction and Oxidative C?H Amination of Cyclic Imines with β-Ketoacids, Org. Lett. 2016, 18, 520?523.

10. Zhen Chen, Shuang-Qing Fan, Yan Zheng, Jun-An Ma*, Silver-Catalyzed Regioselective [3 + 2] Cycloaddition of Arene-diazonium Salts with 2,2,2-Trifluorodiazoethane (CF3CHN2): A Facile Access to 2-Aryl-5-trifluoromethyltetrazoles, Chem. Commun. 2015, 51, 16545-16548.

11. Shuai Wang, Li-Jun Yang, Jun-Liang Zeng, Yan Zheng, Jun-An Ma*, Silver-Catalyzed [3 + 2] Cycloaddition of Isocyanides with Diazo Compounds: New Regioselective Access to 1,4-Disubstituted-1,2,3-triazoles, Org. Chem. Front. 2015, 2, 1468-1474.

12. Shen Li, Jun-An Ma*, Core-structure-inspired asymmetric addition reactions: enantioselective synthesis of dihydrobenzoxazinone- and dihydroquinazolinone based anti-HIV agents, Chem. Soc. Rev. 2015, 44, 7439–7448.

13. Baokun Qiao, Yin-Jun Huang, Jing Nie, Jun-An Ma*, Highly Regio-, Diastereo-, and Enantioselective Mannich Reaction of Allylic Ketones and Cyclic Ketimines: Access to Chiral Benzosultam, Org. Lett. 2015, 17, 4608–4611.

14. Chuan-Le Zhu, Li-Jun Yang, Shen Li, Yan Zheng, Jun-An Ma*, Brine-Stabilized 2,2,2-Trifluorodiazoethane and Its Application in the Synthesis of CF3?Substituted Cyclopropane α-Amino Acids, Org. Lett. 2015, 17, 3442?3445.

15. Zhen-Yan Yang, Tian-Lin Liu, Yan Zheng, Shen Li, Jun-An Ma*, Asymmetric Enynylation of N-Sulfonyl Aldimines Catalyzed by Zn-BINOL Complexes, Eur. J. Org. Chem. 2015, 18, 3905–3912.

16. Yu-Ping Yi, Yan Zheng, Jing Nie, Jun-An Ma*, Oxone-promoted hydration of electron-deficient allenic esters and ketones into 1,3-dicarbonyl compounds, Tetrahedron Lett. 2015, 56(30), 4523–4526.

17. Ai-Jie Cai, Yan Zheng and Jun-An Ma*, Copper-triggered three-component reaction of CF3CHN2, nitriles, and aldehydes: highly diastereoselective synthesis of CF3-substituted oxazolines and vicinal amino alcohols, Chem. Commun. 2015, 51, 8946–8949.

18. Xiao-Dong Tang, Shen Li, Ran Guo, Jing Nie, and Jun-An Ma*, Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β-Keto Acids with 3-Hydroxy-3-indolyloxindoles, Org. Lett. 2015, 17(6), 1389–1392.

19. Ai-Jia Wei, Jing Nie, Yan Zheng, and Jun-An Ma*, Ni-Catalyzed Highly Chemo-, Regio-, and Enantioselective Decarboxylative Aldol Reaction of β,γ-Unsaturated α-Ketoesters with β-Ketoacids, J. Org. Chem., 2015, 80 (8), 3766–3776.

20. Jun-Liang Zeng, Jian Wang, and Jun-An Ma*, New Strategies for Rapid 18F-Radiolabeling of Biomolecules for Radionuclide-Based In Vivo Imaging, Bioconjugate Chem., 2015, 26 (6), 1000–1003.

21. Heng-Ying Xiong, Zhen-Yan Yang, Zhen Chen, Jun-Liang Zeng, Jing Nie, and Jun-An Ma*, Copper-Catalyzed One-Pot Denitrogenative-Dehydrogenative-Decarboxylative Coupling of beta-Ketoacids with Trifluorodiazoethane: Facile Access to Trifluoromethylated Aldol Products, Chem. Eur. J. 2014, 20, 8325–8329.

22. Hua Cai, Jing Nie, Yan Zheng, and Jun-An Ma*, Lithium Binaphtholate-Catalyzed Enantioselective Enyne Addition to Ketones: Access to Enynylated Tertiary Alcohols, J. Org. Chem. 2014, 79, 5484–5493.

23. Fa-Guang Zhang, Yi Wei, Yu-Ping Yi, Jing Nie, and Jun-An Ma*, Regioselective Cycloaddition of Trifluorodiazoethane with Electron-Deficient Allenic Esters and Ketones: Access to CF3?Substituted Pyrazolines and Pyrazoles, Org. Lett. 2014, 16, 3122–3125.

24. Jun-An Ma* and Shen Li, Catalytic fluorination of unactivated C(sp3)–H bonds, Org. Chem. Front. 2014, 1, 712–715.

25. Heng-Xia Zhang, Jing Nie, Hua Cai, and Jun-An Ma*, Cyclic Aldimines as Superior Electrophiles for Cu-Catalyzed Decarboxylative Mannich Reaction of β-Ketoacids with a Broad Scope and High Enantioselectivity, Org. Lett. 2014, 16, 2542–2545.

26. Li-Jun Yang, Shen Li, Shuai Wang, Jing Nie, and Jun-An Ma*, Nucleophilic Lewis Base Dependent Addition Reactions of Allenoates with Trifluoromethylated Cyclic Ketimines. J. Org. Chem. 2014, 79, 3547–3558.

27. Shuai Wang, Jing Nie, Yan Zheng, and Jun-An Ma*, A Direct Copper-Promoted Three-Component Entry to Trifluoromethylketoximes, Org. Lett. 2014, 16, 1606–1609.

28. Ke-Feng Zhang, Jing Nie, Ran Guo, Yang Zheng, Jun-An Ma*, Chiral Phosphoric Acid-Catalyzed Asymmetric Aza-Friedel–Crafts Reaction of Indoles with Cyclic N-Acylketimines: Enantioselective Synthesis of Trifluoromethyl-dihydroquinazolines, Adv. Synth. Catal. 2013, 355, 3497–3502.

29. Hai-Na Yuan, Shen Li, Jing Nie, Yan Zheng, and Jun-An Ma, Highly Enantioselective Decarboxylative Mannich Reaction of Malonic Acid Half Oxyesters with Cyclic Trifluoromethyl Ketimines: Synthesis of β-Amino Esters and Anti-HIV Drug DPC 083, Chem. Eur. J. 2013, 19, 15856–15860.

30. Li-Jun Yang, Shuai Wang, Jing Nie, Shen Li, and Jun-An Ma*, Bisphosphine-Triggered One-Pot Sequential [3 + 2]/[3+ 2] Annulation of Allenoates with Cyclic Ketimines, Org. Lett. 2013, 15, 5214-5217.

31. Feng Li, Jing Nie, Long Sun, Yan Zheng, Jun-An Ma*, “Silver-Mediated Cycloaddition of Alkynes with CF3CHN2: Highly Regioselective Synthesis of 3-Trifluoromethylpyrazoles”, Angew. Chem. Int. Ed. 2013, 52, 6375–6378.

32. Hai-Na Yuan, Shuai Wang, Jing Nie, Wei Meng, Qingwei Yao, and Jun-An Ma*, Hydrogen-Bond-Directed Enantioselective Decarboxylative Mannich Reaction of β-Ketoacids with Ketimines: Application to the Synthesis of Anti-HIV Drug DPC 083, Angew. Chem. Int. Ed. 2013, 52, 3869–3873.

33. Chuan-Le Zhu, Mayaka Maeno, Fa-Guang Zhang, Taiki Shigehiro, Takumi Kagawa, Kosuke Kawada, Norio Shibata*, Jun-An Ma*, and Dominique Cahard*, Chiral N-Fluorodibenzenesulfonimide Analogues for Enantioselective Electrophilic Fluorination and Oxidative Fluorination, Eur. J. Org. Chem. 2013, 29, 6501–6505.

34. Wen-Ting Meng, Yan Zheng, Jing Nie, Heng-Ying Xiong, Jun-An Ma*, Organocatalytic Asymmetric One-pot Sequential Conjugate Addition/ Dearomative-Fluorination: Synthesis of Chiral Fluorinated Isoxazol-5(4H)-ones, J. Org. Chem. 2013, 78, 559–567.

35. Tian-Lin Liu, Heng-Xia Zhang, Yan Zheng, Qingwei Yao, Jun-An Ma*，Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines, Chem. Commun. 2012, 48, 12234–12236.

36. Feng Li, Long Sun, Yuou Teng, Peng Yu, John Cong-Gui Zhao, Jun-An Ma*, Highly Diastereo- and Enantioselective Organocatalytic One-Pot Sequential 1,4-Addition/Dearomative-Fluorination Transformation, Chem. Eur. J. 2012, 18, 14255–14260.

37. Fa-Guang Zhang, Xiao-Yan Zhu, Shen Li, Jing Nie, Jun-An Ma*, Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083, Chem. Commun. 2012, 48, 11552–11554.

38. Wei Meng, Hai-Tao Zhao, Jing Nie, Yan Zheng, Aiping Fu, Jun-An Ma*, “Allenoate-derived 1,5-, 1,7-, and 1,9-zwitterions as highly versatile coupling partners for phosphine-triggered cycloaddition reactions” Chem. Sci. 2012, 3, 3053–3057.

39. Cui-Bo Liu, Wei Meng, Feng Li, Shuai Wang, Jing Nie, Jun-An Ma*, “A Facile Parallel Synthesis of Trifluoroethyl-Substituted Alkynes”, Angew. Chem. Int. Ed. 2012, 51, 6227–6230.

40. Jing Nie, Ming-Qing Hua, Heng-Ying Xiong, Yan Zheng, Jun-An Ma*, Asymmetric Phase-Transfer Catalyzed Conjugate Addition of Glycine Imine to Exocyclic α,β-Unsaturated Ketones: Construction of Polycyclic Imines Containing Three Stereocenters, J. Org. Chem. 2012, 77(9), 4209–4216.

41. Yan Zheng, Heng-Ying Xiong, Jing Nie, Ming-Qing Hua, Jun-An Ma*, Biomimetic Catalytic Enantioselective Decarboxylative Aldol Reaction of β-Ketoacids with Trifluoromethyl Ketones, Chem. Commun. 2012, 48, 4308–4310.

42. Fa-Guang Zhang, Hai Ma, Jing Nie, Yan Zheng, Qingzhi Gao, Jun-An Ma*, Enantioselective Diynylation of Cyclic N-Acyl Ketimines: Access to Chiral Trifluoromethylated Tertiary Carbinamines, Adv. Synth. Catal. 2012, 354, 1422–1428.

43. Feng Li, Jing Nie, Jun-Wei Wu, Yan Zheng, Jun-An Ma*, Stereoselective Synthesis of Fluorinated 2,3-Dihydroquinolin-4(1H)-2-ones via a One-Pot Multistep Transformation, J. Org. Chem. 2012, 77, 2398–2406.

44. Tian-Lin Liu, Hai Ma, Fa-Guang Zhang, Yan Zheng, Jing Nie, Jun-An Ma*, Catalytic enantioselective addition of terminal 1,3-diynes to aromatic ketones: facile access to chiral nonracemic tertiary alcohols, Chem. Commun. 2011, 47, 12873–12875.

45. Lian Wang, Wei Meng, Chuan-Le Zhu, Yan Zheng, Jing Nie, Jun-An Ma*, The Long-Arm Effect: Influence of Axially Chiral Phosphoramidite Ligands on the Diastereo- and Enantioselectivity of the Tandem 1,4-Addition/Fluorination, Angew. Chem. Int. Ed. 2011, 50, 9442–9446.

46. Chuan-Le Zhu, Fa-Guang Zhang, Wei Meng, Jing Nie, Dominique Cahard, Jun-An Ma*, Enantioselective Base-Free Electrophilic Amination of Benzofuran-2(3H)-ones: Catalysis by Binol-Derived P-Spiro Quaternary Phosphonium Salts, Angew. Chem. Int. Ed. 2011, 50, 5869–5872.

47. Guang-Wu Zhang, Wei Meng, Hai Ma, Jing Nie, Wen-Qin Zhang, Jun-An Ma*, “Catalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects, Observation and Practical Implications of Zinc-to-Titanium Transmetalation”, Angew. Chem. Int. Ed. 2011, 50, 3538–3542.

48. Ming-Qing Hua, Lian Wang, Han-Feng Cui, Jing Nie, Xiao-Ling Zhang, Jun-An Ma*, A powerful synergistic effect for highly efficient diastereo- and enantioselective phase-transfer catalyzed conjugate additions, Chem. Commun. 2011, 47, 1631–1633.

49. Jing Nie, Hong-Chao Guo, Dominique Cahard, Jun-An Ma*, Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates, Chem. Rev. 2011, 111, 455–529.

50. Ming-Qing Hua, Han-Feng Cui, Lian Wang, Jing Nie, Jun-An Ma*, Reversal of Enantioselectivity by Tuning the Conformational Flexibility of Phase-Transfer Catalysts, Angew. Chem. Int. Ed. 2010, 49, 2772–2776.

51. Hai Ma, Kun Liu, Fa-Guang Zhang, Chuan-Le Zhu, Jing Nie, Jun-An Ma*, Chiral Bifunctional Thiourea-Catalyzed Enantioselective Michael Addition of Ketones to Nitrodienes, J. Org. Chem. 2010, 75, 1402–1409.

52. Guang-Wu Zhang, Dong-Hua Zheng, Jing Nie, Teng Wang, Jun-An Ma*, Br?nsted Acid-catalyzed Efficient Strecker Reaction of Ketones, Amines and Trimethylsilyl Cyanide, Org. Biomol. Chem. 2010, 8, 1399–1405.

53. J. Nie, G.-W. Zhang, L. Wang, A. Fu, Y. Zheng, Jun-An Ma*, A perfect double role of CF3 groups in activating substrates and stabilizing adducts: the chiral Br?sted acid-catalyzed direct arylation of trifluoromethyl ketones, Chem. Commun., 2009, 2356–2358.

54. Jun-An Ma, Dominique Cahard, Update: Asymmetric Fluorination, Trifluoromethylation and Perfluoroalkylation, Chem. Rev. 2008, 108(9), PR1–43.

55. Guang-Wu Zhang, Lian Wang, Jing Nie, Jun-An Ma*, Chiral Br?nsted Acid-Mediated Enantioselective Organocatalytic Three-component Reaction for the Construction of Trifluoromethyl-containing Molecules, Adv. Synth. Catal. 2008, 350, 1457–1463.

56. Jing Nie, Hong-Wei Zhu, Han-Feng Cui, Ming-Qing Hua, Jun-An Ma*, Catalytic Stereoselective Synthesis of Highly Substituted Indanones via Tandem Nazarov Cyclization and Electrophilic Fluorination Trapping, Org. Lett. 2007, 9, 3053–3056.

57. Han-Feng Cui, Ke-Yan Dong, Guang-Wu Zhang, Lian Wang, Jun-An Ma*, Stereoselective Construction of Fluorinated Indanone Derivatives via a Triple Cascade Lewis Acid-Catalyzed Reaction, Chem. Commun. 2007, 2284–2286.

58. Kun Liu, Han-Feng Cui, Jing Nie, Ke-Yan Dong, Xiao-Juan Li, Jun-An Ma*, Highly Enantioselective Michael Addition of Aromatic Ketones to Nitroolefins Promoted by Chiral Bifunctional Primary Amine-thiourea Catalysts Based on Saccharides, Org. Lett. 2007, 9, 923–925.

59. Jun-An Ma*, Catalytic Asymmetric Synthesis of α- and β-Amino Phosphonic Acid Derivatives, Chem. Soc. Rev. 2006, 35, 630–636.

60. Hong-Chao Guo, Jun-An Ma*, Catalytic asymmetric tandem transformations triggered by conjugate addition, Angew. Chem. Int. Chem. 2006, 45, 354–366.