1. 过渡金属催化的不饱和烃的碳金属化反应研究

2. 过渡金属催化的氟烷基化反应研究

3. 活性药物分子的合成

1994–1998 兰州大学，本科

1998–2003 中科院上海有机化学研究所，研究助理 (导师：麻生明院士)

2004–2009 美国Purdue University，博士 (导师：Ei-ichi Negishi)

2009–2011 美国Purdue University，博士后

2011–2014 上海源力生物技术有限公司(恒瑞医药)，研发部主任

2014.6 – 至今 天津大学，研究员

1、本科生课程：《有机化学》(侯德榜英才班),《精细合成化学》,《有机化学(全英文)》(留学生班),《有机化学实验》等。

2、研究生课程：《金属有机化学》

主持研究生全英文课程(金属有机化学)建设

主编教材《有机化学(第六版)学习指南》

参编教材《有机化学》(第六版)

天津大学理学院2018-2019年度优秀共产党员

天津大学理学院2018年度优秀教师奖

天津大学2016,2017,2019,2020届本科毕业设计(论文)优秀指导教师

2009年Herbert C. Brown有机化学研究生奖

2008年Negishi研究室杰出贡献奖

55. Zhou, S.; Hou, X.; Yang, K.; Guo, M.; Zhao, W.; Tang, X.; Wang, G.* Direct Synthesis of N-Difluoromethyl-2-pyridones from Pyridines.J.Org.Chem.2021,86,in revision.

54. Chen, H.; Wang, L.; Liu, Y.; Zhao, W.; Tang, X.; Guo, M.;Wang, G.* Copper catalyzed direct synthesis of unsymmetrically substituted oxalamides from bromodifluoroacetamide and tertiary amines. Asian J.Org.Chem.2021,accepted. DOI: 10.1002/ajoc.202100044.

53. Zhou, S.; Sun, Z.-Y.; Zhu, K.; Zhao, W.; Tang, X.; Guo, M.;Wang, G.* Metal-Free Difunctionalization of Pyridines: Selective Construction ofN-CF₂H andN-CHO Dihydropyridines. Org.Lett.2021,23,in press. DOI: 10.1021/acs.orglett.1c00352

52. Hou, X.; Zhou, S.; Li, Y.; Guo, M.*; Zhao, W.; Tang, X.; Wang, G.* Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate.Org.Lett.2020,22, 9313-9318. DOI: 10.1021/acs.orglett.0c03540

51. Chen, H.; Yang, Y.; Wang, L.; Niu, Y.; Guo, M.; Zhao, W.; Tang, X.; Wang, G.* Slicing and Splicing of Bromodifluoro-N-arylacetamides: Dearomatization and Difunctionalization of Pyridines.Org.Lett.2020,22, 6610-6616. DOI: 10.1021/acs.orglett.0c02368

50. Sun, Z.-Y.; Zhou, S.; Yang, K.; Guo, M.; Zhao, W.; Tang, X.;Wang, G.* Tetrahydroxydiboron-Promoted Radical Addition of Alkynols.Org.Lett.2020,22, 6214-6219. DOI: /10.1021/acs.orglett.0c02367

49. Dai, Q.; Lin, J.; Cao, H.; Zhao, H.*; Yu, G.; Li, C.; Wang, T.; Shi, Y.; Wang, G.* Gong, J.* Gas–water interface engineered exceptional photoconversion of fatty acids to olefins.Green Chem.2020,22, 7848-7857. DOI: 10.1039/d0gc02237c

48. Ma, N.;Wang, G.*; Zhang, W.* Explanation of “Nomenclature of Organic Compounds-2017”: Comparison of Nomenclature Rules and Nomenclature of Common Substituent Groups.Univ. Chem.2019, 34, 116？120.

47. Zhu, X.; Zhang, Y.; Ren, X.; Yao, J.; Guo, S.; Zhang, L.; Wang, D.;Wang, G.; Zhang, X.; Li, R.;* Hu, W. 2D Molecular Crystal Bilayer p–n Junctions: A General Route toward High-Performance and Well-Balanced Ambipolar Organic Field-Effect Transistors.Small2019, 1902187. DOI: 10.1002/smll.201902187

46. Zhao, S.; Wang, X.; Wang, P.;Wang, G.*; Zhao, W.; Tang, X.;* Guo, M.* BF₃·OEt₂？Promoted Propargyl Alcohol Rearrangement/[1,5]-Hydride Transfer/Cyclization Cascade Affording Tetrahydroquinolines.Org.Lett.2019,21, 3990-3993. DOI: 10.1021/acs.orglett.9b01153

45. Yang, Y.; Yuan, F.; Ren, X.;Wang, G.*; Tang, X.; Zhao, W.; Guo, M.* Copper-Catalyzed Oxydifluoroalkylation of Hydroxyl-Containing Alkenes J. Org. Chem.2019,84, 4507？4516. DOI: 10.1021/acs.joc.9b00121

44. Dai, Q.; Zhao, H.;* Cao, H.; Yang, J.; Zhao, W.; Wang, T.;* Liu, L.; Fan, Z.;Wang, G. Photo-triggered conversion of hydrophilic fluorescent biomimetic nanostructures for cell imaging.Chem.Commun.2019,55, 596-599. DOI: 10.1039/c8cc07197g

43. Liu, J.; Wang, G.N,N,N’,N’’,N’’ -Pentamethyldiethylenetriamine. InEncyclopedia of Reagents for Organic Synthesis, Wiley, 2019.4.1.

42. Zhou, S.; Yuan, F.; Guo, M.;Wang, G.*; Tang, X.; Zhao, W.* Switchable synthetic strategy toward trisubstituted and tetrasubstituted exocyclic alkenes.Org.Lett.2018,20, 6710-6714. DOI: 10.1021/acs.orglett.8b02814

41. Yuan, F.; Zhou, S.; Yang, Y.; Guo, M.; Tang, X.;Wang, G.* Copper Catalyzed One-Pot Difluoroalkylation and Lactonization of Unsaturated Carboxylic Acids.Org.Chem. Front. 2018,5, 3306-3309. DOI: 10.1039/C8QO00940F

40. Wang, X.; Liu, J.; Yu, Z.; Guo, M.; Tang, X.;Wang, G.* Desulfonylation-Initiated Distal Alkenyl Migration in Copper-Catalyzed Alkenylation of Unactivated Alkenes.Org.Lett.2018,20, 6516-6519. DOI: 10.1021/acs.orglett.8b02840

39. Dai, Q.; Zhao, H.;* Fan, Z.; Zhao, W.; Wang, G.;* Zhang, J.; Hou, R.; Du, P.; Cao, H.* In Situ Nanoreactors: Controllable Photoluminescent Carbon-Rich Polymer Nanodots Derived from Fatty Acid under Photoirradiation.Macromol. Rapid Commun. 2018,39, 1800152. DOI: 10.1002/marc.201800152

38. Feng, X.; Wang, X.; Chen, H.; Tang, X.; Guo, M.; Zhao, W.;*Wang, G.* Copper-Mediated Regioselective Hydrodifluoroalkylation of Alkynes.Org. Biomol. Chem.,2018,16, 2841-2845. 10.1039/C8OB00256H

37. Wang, X.; Li, M.; Yang, Y.; Guo, M.;* Tang, X.; Wang, G.* One-pot Construction of Difluorinated Pyrrolizidine and Indolizidine Scaffolds via Copper-Catalyzed Radical Cascade Annulation.Adv. Synth. Cat. 2018,360, 2151-2156. DOI: 10.1002/adsc.201701643

36. Li, Y.; Liu, J.; Zhao, S.; Du, X.; Guo, M.;* Zhao, W.; Tang, X.; Wang, G.* Copper-Catalyzed Fluoroolefination of Silyl Enol Ethers and Ketones towards the Synthesis of β-Flouroenones.Org.Lett.2018,20, 917？920. DOI: 10.1021/acs.orglett.7b03700

35.Wang, G.; Ma, J.-A. NFSI and its analogs electrophilic fluorination for preparing alkyl fluorides, InFluorination.Synthetic Organofluorine Chemistry, vol 1, Hu, J.; Umemoto, T., Eds, Springer, Singapore 2018, Chap. 6.1 (DOI: 10.1007/978-981-10-1855-8_6-1).

34. Chen, H.; Wang, X.; Guo, M.; Zhao, W.; Tang, X.;* Wang, G.* Highly Efficient and Versatile Synthesis of α,α-Difluoro-γ-lactams via Aminodifluoroalkylation of Alkenes.Org.Chem. Front. 2017,4, 2403-2407. DOI: 10.1039/c7qo00611j

33. Li, H.; Ren, X.; Zhao, W.;* Tang, X.; Wang, G.* The cross-coupling of directed C-H and organometallic reagents for C-C bond formation.Chin. J. Org. Chem. 2017,37, 2287-2302. DOI: 10.6023/cjoc201703036

32. Wang, X.; Zhao, S.; Liu, J.; Zhu, D.; Guo, M.;* Tang, X.;* Wang, G.* Copper-Catalyzed C？H Difluoroalkylations and Perfluoroalkylations of Alkenes and (Hetero)arenes.Org. Lett. 2017,19, 4187-4190.

31. Jing, H.; Feng, X.; Guo, M.; Zhou, S.; Li, Y.; Zhang, J.; Zhao, W.;* Tang, X.; Wang, G.* Copper-catalyzed regioselective formal allylboration of arylsubstituted terminal alkynes with bis(pinacolato)diboron and allyl halides/sulfonates.Asian J. Org. Chem. 2017,6, 1375-1379. DOI: 10.1002/ajoc.201700263

30. Zhang, H.; Ren, X.; Zhao, W.;* Tang, X.; Wang, G.* One-pot Synthesis ofp-Amino-substituted Unsymmetrical Benzils and Benzil Derivatives.Adv. Synth. Cat. 2017,359, 395-401. DOI: 10.1002/adsc.201600389

29. Wu, J.; Wang, D.; Chen, X.; Gui, Q.; Li, H.; Tan, Z.;* Huang, G.;* Wang, G.* Synthesis of 4-benzylpyridines via Pd-catalyzed CH₃-arylation of 4-picoline.Org. Biomol. Chem.,2017,15, 7509–7512. DOI: 10.1039/c7ob01726j

28. Chen, X.; Tan, Z.;* Gui, Q.; Hu, L.; Liu, J.; Wu, J.; Wang, G.* Photocatalytic/Cu-promoted C-H activations: Visible-light-induced ortho-selective perfluoroalkylation of benzamides.Chem. Eur. J. 2016,22, 6218–6222. DOI: 10.1002/chem.201600229

27. Du, J.; Xu. G.; Lin, H.;Wang, G.;* Tao, M.;* Zhang, W.* Highly efficient reduction of carbonyls, azides, and benzyl halides by NaBH₄ in water catalyzed by PANF-immobilized quaternary ammonium salts.Green Chem. 2016,18, 2726–2735. DOI: 10.1039/c5gc02621k

26. Du, J.; Shuai, B.; Tao, M.;*Wang, G.;* Zhang, W.* Pyrrolidine modified PANF catalyst for asymmetric Michael addition of ketones to nitrostyrenes in aqueous phase.Green Chem. 2016,18, 2625–2631. DOI: 10.1039/c5gc02622a

25. Ren, X.; Wang, G.; Tang, X.; Zhao, W.* Iodine-Catalyzed One-Pot Synthesis of α-Ketoamides from Unsaturated Hydrocarbons.Chin. J. Org. Chem. 2015,35, 1733-1738. DOI: 10.6023/cjoc201502014

24.Wang, G.; Xu, S.; Hu, Q.; Zeng, F.; Negishi, E.,* Search for Highly Efficient, Stereoselective, and Practical Synthesis of Complex Organic Compounds of Medicinal Importance as Exemplified by the Synthesis of the C21-C37 Fragment of Amphotericin B,Chem.Eur. J. 2013,19, 12938-12942.

23. Xu, S.; Lee, C.-T.;Wang, G.; Negishi, E.,* Widely Applicable Synthesis of Enantiomerically Pure Tertiary Alkyl-Containing 1-Alkanols by Zirconium-Catalyzed Asymmetric Carboalumination of Alkenes and Palladium- or Copper-Catalyzed Cross-Coupling,Chem. Asian J. 2013,8, 1829-1835.

22.Wang, G.; Mohan, S.; Negishi, E.,* Highly (≥98%) Selective Synthesis of Conjugated Dienoic and Trienoic Esters of All Possible Configurations Consisting ofE and/orZ Disubstituted Alkenes via Alkyne Elementometalation–Pd-Catalyzed Cross-Coupling,Proc. Natl. Acad. Sci. USA,2011,108, 11344-11349.

21.Wang, G.; Yin, N.; Negishi, E.,* Highly Selective Total Synthesis of Fully Hydroxy-Protected Mycolactones A & B and Their Stereoisomerization upon Deprotection,Chem. Eur. J. 2011,17, 4118-4130.

20. Negishi, E.;* Wang, G.; Xu, Z., Alkyne Elementometalation–Pd-Catalyzed Cross-Coupling. Towards Synthesis of Any Alkenes in High Yields, Efficiently, Selectively, Economically, and Safely–“Green” Way,J. Org. Chem. 2010,75, 3151-3182.

19. Pitsinos, E.; Athinaios, N.; Xu, Z.;Wang, G.; Negishi, E.,* A Highly Convergent Total Synthesis of (+)-Scyphostatin,Chem. Comm. 2010,46, 2200-2202.

18. Negishi, E.;* Wang, G., Synthesis of Alkenes from Alkynes by Carbometallation and Subsequent Coupling Reactions,Science of Synthesis,Vol. 47, Jacobsen, E. N.; de Meijere, A.; Eds., Thieme, Stuttgart,2009, Chap. 47.1.5.4, 971-1016.

17. Negishi, E.;* Wang, G., Synthesis of Alkenes from Alkynes by Hydrometallation and Subsequent Coupling Reactions,Science of Synthesis,Vol. 47, Jacobsen, E. N.; de Meijere, A.; Eds., Thieme, Stuttgart,2009, Chap. 47.1.5.3, 909-970.

16. Negishi, E.;* Wang, G., Synthesis of 1,3-Dienes by Metal-Mediated Coupling Reactions,Science of Synthesis, Vol. 46, Rawal, V.; Kozmin, S., Eds, Thieme, Stuttgart,2009, Chap. 46.6, 239-352.

15.Wang, G.; Huang, Z.; Negishi, E.,* Highly stereoselective and Efficient Synthesis of w-Heterofunctional Di and Trienoic Esters for Horner-Wadsworth-Emmons Reaction via Alkyne Hydrozirconation and Pd-Catalyzed Alkenylation,Tetrahedron Lett.2009,50, 3220-3223.

14.Wang, G.; Negishi, E.,* AlCl₃-Promoted FacileE-to-Z Isomerization Route to (Z)-2-Methyl-1-buten-1,4-ylidene Synthons for Highly Efficient and Selective (Z)-Isoprenoid Synthesis,Eur. J. Org. Chem. 2009, 1679-1682.

13. Wang, G.; Huang, Z.; Negishi, E.,* Efficient and Selective Syntheses of (all-E)- and (6E, 10Z)-2’-O-Methylmyxalamides D via Pd-Catalyzed Alkenylation–Carbonyl Olefination Synergy,Org. Lett.2008,10, 3223-3226.

12. Negishi, E.;* Huang, Z.;Wang, G.; Mohan, S.; Wang, C.; Hattori, H., Recent Advances in Efficient and Selective Synthesis of Di-, Tri-, and Tetrasubstituted Alkenes via Pd-Catalyzed Alkenylation–Carbonyl Olefination Synergy,Acc. Chem. Res.2008,41, 1474-1485.

11.Wang, G.; Zhu, G.; Negishi, E.,* Zirconium-catalyzed methylalumination of heterosubstituted arylethynes: Factors affecting the regio-, stereo-, and chemoselectivities,J. Organomet. Chem. 2007,692, 4731-4736.

10. Negishi, E.;* Hu, Q.; Huang, Z.;Wang, G.; Yin, N., Palladium- or Nickel-Catalyzed Cross-Coupling with Organozincs and Related Organometals, inThe Chemistry of Organic Zinc Compounds, Rappoport, Z., Ed., Wiley,2006, p. 457-553.

9. Negishi, E.;* Wang, G.; Zhu, G., Palladium-Catalyzed Cyclization via Carbopalladation and Acylpalladation, inTopics in Organometallic Chemistry. Metal Catalyzed Cascade Reactions, Müller, T.J.J., Ed., Springer, Berlin,2006, Vol. 19, p. 1-48.

8. Yin, N.;Wang, G.; Qian, M.; Negishi, E.,* Highly Stereoselective Synthesis of the Side-Chains of Mycolactones A and B Featuring Stepwise Double Substitutions of 1,1-Dibromo-1-alkenes,Angew. Chem. Int. Ed.,2006,45, 2916-2920.

7. Negishi, E.;* Hu, Q.; Huang, Z.; Qian, M.;Wang, G., Palladium-Catalyzed Alkenylation via Negishi Coupling,Aldrichim. Acta,2005,38, 71-88.

6. Ma, S.;* Wang,G.,Regioselectivity Control by A Ligand Switch in the Coupling Reaction Involving Allenic/Propargylic Palladium Species,Angew. Chem. Int. Ed. 2003,42, 4215-4217.

5. Ma, S.;* Wang,G., Unexpected S_N2’-Type Addition-Elimination Reactions of 1-Aryl-2, 3-Allenols with LiX. Synthesis and Synthetic Application of 1-Aryl-3-halo-1, 3-dienes,Tetrahedron Lett. 2002,43, 5723-5726.

4. Ma, S.;* Hou, H.; Zhao, S.;Wang, G., Efficient Synthesis of Optically Active 2, 3-Allenols via the Simple CuBr-Mediated Reaction of Optically Active Propargylic Alcohols with Paraformaldehyde,Synthesis 2002, 1643-1645.

3. Ma, S.;* Xie, H.; Wang, G.; Zhang, J.; Shi, Z., Hydrohalogenation Reaction of Substituted 1, 2-Allenic Carboxylic Acids, Esters, Amides, Nitriles, and Diphenyl Phosphine Oxides,Synthesis 2001, 713-730.

2. Ma, S.;* Li, L.; Wei, Q.; Xie, H.; Wang, G.; Shi, Z.; Zhang, J., Hydrohalogenation Reaction of Electron-Deficient Allenes,Pure&Appl. Chem. 2000,72, 1739-1743.

1. Ma, S.;* Wang,G., Highly Selective Hydrohalogenation Reaction of Substituted 2, 3-Allenoates,Chin. J. Chem. 1999, 17, 545-549.