针对钛族金属(锆、钛)催化的局限性,课题组采用 “原位构建低价锆、钛催化活性物种”策略,通过脱氢的方式原位构建了低价的锆、钛活性物种,进一步采用“协同活化再生”策略,在促进M−N, M−O(M=锆、钛)键断裂基础上,实现了锆、钛催化剂的循环再生。在此基础上开展了锆、钛催化的烯烃脱氢硼化,(内) 烯烃1,1−二硼化,卤代烷烃脱卤硼化,含氮杂环以及羧酸衍生物彻底还原等使用其他金属暂时难以实现的一些反应。研究工作拓展了锆、钛活化新模式与催化新应用,突破了锆、钛自身的催化限制,展现了其独特且与后过渡金属互补的反应活性,形成了特色较为鲜明的研究体系。在上述工作基础上,2018年独立工作以来以通讯作者发表J. Am. Chem. Soc. 2篇,Angew. Chem. Int. Ed. 9篇,Nat. Commun. 2 篇,ACS Catal. 1篇及其他研究论文多篇。2018年以来申请国内专利16项,已授权14项,申请PCT专利1项。
1. Wendi Yang, Ximei Tian, Shuhui Tong, Min Jiang,* Wei Zhang,* and Lipeng Wu* Titanium-Catalyzed Synthesis of Multisubstituted Glutarimides Bearing Quaternary Carbon Centers – Scope, Mechanism, and Bioactivity Studies Angew. Chem. Int. Ed., 2026, 64, e202509778. (links)
2. Yaqiong Wang, Jiong Zhang, Yin Zhang, Fang Wang,* and Lipeng Wu* Synthesis of functionalized hydrosilanes via titanium-catalyzed hydroboration and hydrogenation of C(sp3)–Si bonds in silacyclobutanes Nat. Commun. 2026, 17, 7499. (links)
3. Yaqiong Wang, Jiong Zhang, Fang Wang, and Lipeng Wu* Titanium-Catalyzed Reaction of Silacyclobutanes with Alkenes: Mimicking the Reactivity and Reversing the Selectivity Towards Late Transition Metals Angew. Chem. Int. Ed., 2025, 64, e202420092. (links)
4. Xiaoxian Li,+ Ximei Tian,+ Haijun Jiao,* and Lipeng Wu* Titanium-Catalyzed C−X and C−H Borylation of Aryl Halides for the Synthesis of Bis(boronate)benzenes Angew. Chem. Int. Ed., 2025, e202509778. (links)
5. Jiong Zhang, Ximei Tian, Yaqiong Wang, Yin Zhang, Fang Wang,* and Lipeng Wu* Borane-Catalyzed Intermolecular Aryl Transfer between Hydrosilanes: Shifting the Equilibrium by Removal of a Gaseous Hydrosilane J. Am. Chem. Soc. 2024, 146, 33349–33358. (links)
6. Chunping Ren, Bo Han, Hui Guo, Wendi Yang, Chungu Xia, Xu-hui Jin,* Fang Wang,* and Lipeng Wu* Skeletal Editing of Aromatic N-Heterocycles via Hydroborative Cleavage of C−N Bonds – Scope, Mechanism, and Property Angew. Chem. Int. Ed., 2024, 63, e202407222. (links)
7. Sida Li, Chaopeng Hu, Liu Leo Liu,* and Lipeng Wu* Selective Hydroboration of C−C Single Bonds without Transition-metal Catalysis Angew. Chem. Int. Ed., 2024, 63, e202412368. (links)
8. Sida Li, Haijun Jiao,* Xing-zhong Shu, and Lipeng Wu* Zirconium and Hafnium Catalyzed C–C Single Bond Hydroboration Nat. Commun. 2024, 15, 1846. (links)
9. Jiong Zhang, Rui Wei, Chunping Ren, Liu Leo Liu,* and Lipeng Wu* Si–B Functional Group Exchange Reaction Enabled by a Catalytic Amount of BH3: Scope, Mechanism, and Application J. Am. Chem. Soc. 2023, 145, 15619–15629. (links)
10. Bo Han, Chunping Ren, Min Jiang and Lipeng Wu* Titanium-Catalyzed Exhaustive Reduction of Oxo-Chemicals Angew. Chem. Int. Ed., 2022, 61. e202209232. (links)
11. Sida Li, Chenyang Hu, Xin Cui, Jiong Zhang, Liu Leo Liu,* and Lipeng Wu* Site-Fixed Hydroboration of Terminal and Internal Alkenes using BX3/iPr2NEt Angew. Chem. Int. Ed., 2021, 60. 26238-26245. (links)
12. Xianjin Wang, Penglei Cui, Chungu Xia,* and Lipeng Wu* Catalytic Boration of Alkyl Halides with Borane without Hydrodehalogenation Enabled by Titanium Catalyst Angew. Chem. Int. Ed. 2021, 60, 12298-12303. (links)
13. Xianjin Wang, Xin Cui, Sida Li, Yue Wang, Chungu Xia,* Haijun Jiao,* and Lipeng Wu* Zirconium‐Catalyzed Atom‐Economical Synthesis of 1,1‐Diborylalkanes from Terminal and Internal Alkenes Angew. Chem., Int. Ed., 2020, 59, 13608-13612. (links)
14. Xiaonan Shi, Sida Li, and Lipeng Wu* H2‐Acceptorless Dehydrogenative Boration and Transfer Boration of Alkenes Enabled by Zirconium Catalyst Angew. Chem., Int. Ed., 2019, 58, 16167-16171. (links)